LACTOGG® Probiotic - SCIENTIFIC STUDIES

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Promotes gut health

● Improves symptoms of Irritable Bowel Syndrome

● Improves symptoms of Functional Abdominal Pain

● Reduces stomach irritation and helps to heal gastric ulcers

Many people suffer from a condition called Irritable Bowel Syndrome (IBS). The symptoms of IBS are usually abdominal windiness, bloating, colic and either diarrhoea or constipation.

No one knows what the actual cause of IBS is but research indicates that people suffering from IBS tend to have inflammation in the intestines, abnormal “leakiness” in their intestines as well as irregular patterns of contraction of the intestines.

In children, a condition called Functional Abdominal Pain (FAP) is also common. In this condition children have repeated episodes of abdominal pain without any apparent physical reason.

Both IBS and FAP are very difficult to treat. Clinical studies have indicated that GG probiotic can reduce the symptoms of these two common conditions.

How should LACTOGG^® be taken?

Babies and children:

1 sachet or 1 capsule a day

Adults:

At least 1 sachet or 1 capsule a day

References:

Bruzzese E et al. Disrupted intestinal microbiota and intestinal inflammation in children with cystic fibrosis and its restoration with Lactobacillus GG: A randomised clinical trial. PLoS One, 2014;9(2):e87796

Commane DM et al. Effects of fermentation products of pro-and prebiotics on trans-epithelial electrical resistance in an in vitro model of the colon. Nutr Cancer 2005:51:102-109

Donato KA et al. Lactobacillus rhamnosus GG attenuates interferon-ɣ and tumor necrosis factor-ɑ-induced barrier dysfunction and pro-inflammatory signalling. Microbiology 2010, 156, 3288–3297

Tao Y et al. Soluble factors from Lactobacillus GG activate MAPKs and induce cytoprotective heat shock proteins in intestinal epithelial cells. Am J Physiol Cell Physiol 2006;290:C1018-30

Yan F et al. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 2007;132:562-75

Yan F et al. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem 2013;288(42) 30742-51

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Hong Kong Tel: +852 3486 7233 Fax: +852 3486 3723 China Guangzhou Synthgensys Biotechnology Co. Ltd. Unit 501-1, No. 7, Spiral 4 Road, Guangzhou
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Singapore ProbioCare Pte. Ltd. (201603757R) 32 Ean Kiam Place
Singapore 429119 Tel: +65 6255 5592 Fax: +65 6255 5563 Malaysia ProbioCare Sdn. Bhd. (1124987-P) 122 Jalan Ipoh
51200 Kuala Lumpur
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Pathumwan, Bangkok 10330, Thailand Tel: +66 99 2828338